Selected Projects

DESIRE

Development of Epilepsy – Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy

DESIRE will focus on epileptogenic developmental disorders (EDD), i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cognitive and behavioral impairments. EDD are the most frequent drugresistant pediatric epilepsies carrying a lifelong perspective of disability and reduced quality of life. Although EDD collectively represent a major medical and socio-economic burden, their molecular diagnosis, pathogenic mechanisms (PM) and rationale treatment are poorly understood.

Specific objectives of DESIRE are to advance the state of the art with respect to:

1.    the genetic and epigenetic causes and PM of EDD, particularly epileptogenic MCD, to elucidate molecular networks and disrupted protein complexes and search for common bases for these apparently heterogeneous disorders.

2.    the diagnostic tools (biomarkers) and protocols through the study of a unique and well-characterized cohort of children to provide standardized diagnosis for patient stratification and research across Europe.

3.    treatment of EDD using randomized, multidisciplinary clinical protocols and testing preclinical strategies in experimental models to also address novel preventative strategies.

Consortium: 26 partners from 11 countries

Coordinator of the project:  Department of Neuroscienze, Psicologia, Area del farmaco e salute del bambino, Università degli Studi di Firenze  –  Italy

Funding programme: FP7-HEALTH

Project start: October 2013

End date for the project: 30 September 2018

For more information go to the website www.epilepsydesireproject.eu

ADIDAS ORIGINALS Dragon W Tribe Blue S14 Joy Orchid S13 Running White Ftw Mens AF Sherpa Lined Vest AF 2016 ADIDAS ORIGINALS Top ten hi sleek w BLACK 1 WHITE BLACK 1 Cheap Womens AF Sugarlips Long Seamless Cami 2016 Adidas Men Originals CLOT Track Jacket Cheap Womens AF Vegan Leather Biker Jacket 2016 ADIDAS PERFORMANCE Barricade Team 3 W FTWR White Core Black Light Grey New Womens AF High Rise Cropped Flare Sateen Pants 2016 ADIDAS ORIGINALS Extaball W Noiess Ormeta Nuiflu New Womens AF Lace Soft Shorts 2016 ADIDAS PERFORMANCE Galactic Elite W Violet Argmet Viobri New Womens AF Ribbed Knit Skirt 2016 ADIDAS PERFORMANCE Duramo Sleek W NOIR1 BLANC NOIR1 Mens AF Classic Chambray Shirt AF 2016 ADIDAS ORIGINALS Zx 700 W Sabpou Sabpou Noiess Cheap Womens AF Cutoff Logo Graphic Hoodie 2016 ADIDAS ORIGINALS Gazelle og w Rosecl Blacas Ormeta Cheap Womens AF 2-in-1 Nylon Jacket 2016 Adidas Men Originals Plimcana 2 0 Low Shoes Sale Mens AF Jogger Sweatpants Online ADIDAS ORIGINALS Zx Flux W Seroso Noiess Blacas Mens AF Distressed Logo Graphic Sweatshirt AF 2016 ADIDAS PERFORMANCE Response Aspire Str W Running White Ftw Black 1 Vivid Mint F14 Cheap Womens AF Multi-Directional Pinstripe Shirt 2016 ADIDAS PERFORMANCE 3 Series 2014 Black 1 Running White Ftw Light Scarlet Cheap Womens AF Sleeveless Crop Sweater 2016 Adidas Women Training Sport Essentials The Hoodie Cheap Womens AF Sleeveless Turtleneck Sweater 2016 Adidas Men Originals Stan Smith Made in Germany Shoes Mens AF Cotton Cardigan AF 2016